Reaktionsgleichung
Cl.N(CCCCC(N)=O)C(N)=N.Cl.Cl.NCCCNCCCCNC(=O)C(O)O.C(O)(=O)CCCC(O)=O.Cl.Cl.Cl.[NH2:42][CH2:43][CH2:44][CH2:45][NH:46][CH2:47][CH2:48][CH2:49][CH2:50][NH:51][C:52](=[O:66])[CH:53]([NH:55][C:56](=[O:65])[CH2:57][CH2:58][CH2:59][CH2:60][NH:61][C:62]([NH2:64])=[NH:63])[OH:54]>O>[NH2:42][CH2:43][CH2:44][CH2:45][NH:46][CH2:47][CH2:48][CH2:49][CH2:50][NH:51][C:52](=[O:66])[CH:53]([NH:55][C:56](=[O:65])[CH2:57][CH2:58][CH2:59][CH2:60][NH:61][C:62]([NH2:64])=[NH:63])[OH:54]Komponenten
6
Edukt 4
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 60 °C
Versuchsvorschrift
A mixture of 92.4 mg (0.48 mmole) of 5-guanidino pentanamide hydrochloride, 166.5 mg (0.57 mmole) of N-[4-(3-aminopropyl)aminobutyl]-2,2-dihydroxyethanamide dihydrochloride, 62.8 mg (0.48 mmole) of glutaric acid and 0.1 ml of water was heated at 60° C. for 24 hours. After completion of the reaction, 5 ml of water was added to the reaction mixture which was then purified in a manner similar to that in Example 1, using CM-Sephadex® C-25 (Na-type) and Sephadex® LH-20 to obtain 82.5 mg (37.1% yield) of a white powder of N-[4-(3-aminopropyl)aminobutyl]-2-(5-guanidinopentanamido)-2-hydroxyethanamide trihydrochloride.
Aufarbeitung
- additionwas added to the reaction mixture which
- customwas then purified in a manner similar to that in Example 1
Quellen und Nachweise
- ORD-Eintrag
- ord-245c3b8d4f45489997d738fce95b00cb
- Quelldatensatz
- uspto-grants-1991_01
- Patentnummer
- US04983328
Verknüpfte Notizen
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