Pyridine → (E)-1-[3-(4-Chlorophenoxy)phenyl]buten-3-one oxime

HRID 704814

Reaktionsgleichung

Reaktionsgleichung von HRID 704814
[Cl:1][C:2]1[CH:19]=[CH:18][C:5]([O:6][C:7]2[CH:8]=[C:9](/[CH:13]=[CH:14]/[C:15](=O)[CH3:16])[CH:10]=[CH:11][CH:12]=2)=[CH:4][CH:3]=1.Cl.[NH2:21][OH:22].N1C=CC=CC=1>CO.CCOCC>[Cl:1][C:2]1[CH:19]=[CH:18][C:5]([O:6][C:7]2[CH:8]=[C:9](/[CH:13]=[CH:14]/[C:15](=[N:21][OH:22])[CH3:16])[CH:10]=[CH:11][CH:12]=2)=[CH:4][CH:3]=1

Komponenten

6

Edukt 3

HCID 1049PyridineHCID 443297Hydroxyamine hydrochlorideHCID 20073366(E)-1-[3-(4-Chlorophenoxy)phenyl]buten-3-one

Produkt 1

HCID 86744553(E)-1-[3-(4-Chlorophenoxy)phenyl]buten-3-one oximeAusbeute 101,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

The product from step (a) (19 g) and hydroxylamine hydrochloride (6.9 g) were taken up in methanol (100 ml), pyridine (20 ml) was added and the mixture stirred for 1 hour. The mixture was then stripped, redissolved in ether (200 ml), washed with 2 N aqu. HCl and satd. aqu. NaCl, dried over MgSO4, and stripped to give the desired product (20.3 g).

Aufarbeitung

  1. washwashed with 2 N aqu
  2. dry with materialNaCl, dried over MgSO4

Quellen und Nachweise

ORD-Eintrag
ord-8ac384bb3aa048a7a33174f8bc9c7ce6
Quelldatensatz
uspto-grants-1991_01
Patentnummer
US04988733

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