Potassium Sodium Tartrate → (1-(propan-2-yl)-1H-pyrazol-3-yl)methanol
Reaktionsgleichung
[CH:1]([N:4]1[CH:8]=[CH:7][C:6]([C:9](OCC)=[O:10])=[N:5]1)([CH3:3])[CH3:2].[Al].[Li].[C@H](O)(C([O-])=O)[C@@H](O)C([O-])=O.[Na+].[K+]>C(OCC)C.O1CCCC1>[CH:1]([N:4]1[CH:8]=[CH:7][C:6]([CH2:9][OH:10])=[N:5]1)([CH3:3])[CH3:2]Komponenten
6
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Reaktionsbedingungen
- Temperatur
- 0 °C
Versuchsvorschrift
Commercially available ethyl 1-isopropyl-1H-pyrazole-3-carboxylate was dissolved in diethyl ether, the solution was cooled to 0° C., and a 1M lithium aluminum solution in tetrahydrofuran was added. After stirring for 3 hours, the reaction mixture was poured into a cold 30% aqueous Rochelle's salt solution and was allowed to stir for one hour. The resulting mixture was extracted twice with diethyl ether. The combined organic extracts were washed with 10% aqueous potassium carbonate solution and brine, dried over sodium sulfate, and concentrated under reduced pressure to yield the desired compound (54% yield).
Aufarbeitung
- stirringto stir for one hour
- extractionThe resulting mixture was extracted twice with diethyl ether
- washThe combined organic extracts were washed with 10% aqueous potassium carbonate solution and brine
- dry with materialdried over sodium sulfate
- concentrationconcentrated under reduced pressure
Quellen und Nachweise
- ORD-Eintrag
- ord-d567bbe7504a457190e71362a7d54f70
- Quelldatensatz
- uspto-grants-2015_11
- Patentnummer
- US09174981B2
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