Water → 6-Fluoroimidazo[1,2-a]pyridine-3-carboxylic acid

Reaktionsgleichung

[F:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([C:11]([O:13]CC)=[O:12])=[CH:9][N:10]=2)[CH:7]=1.O.[OH-].[Li+].O.C1COCC1>C(O)C>[F:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([C:11]([OH:13])=[O:12])=[CH:9][N:10]=2)[CH:7]=1

Komponenten

Edukt 4

HCID 962Water

HCID 8028Tetrahydrofuran

HCID 168937Lithium hydroxide, monohydrate

HCID 67976050Ethyl 6-fluoroimidazo[1,2-a]pyridine-3-carboxylate

Produkt 1

HCID 552681956-Fluoroimidazo[1,2-a]pyridine-3-carboxylic acidAusbeute 100,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

Reaktionsbedingungen

Temperatur: 65 °C

Versuchsvorschrift

Ethyl 6-fluoroimidazo[1,2-a]pyridine-3-carboxylate (0.10 g, 0.48 mmol) and lithium hydroxide monohydrate (0.020 g, 0.48 mmol) were added to a mixture of water, THF and ethanol (1:2:1) and heated in a sealed vial at 65° C. for 6 hours. The solvent was removed by rotary evaporation to yield 87 mg of the desired product. MS (ES+APCI) m/z=181.1 (M+H).