Lithium Hydroxide → 1-(3-Fluorophenyl)-2-oxo-1,2-dihydropyridine-4-carboxylic acid

HRID 711279Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 711279
[F:1][C:2]1[CH:3]=[C:4]([N:8]2[CH:13]=[CH:12][C:11]([C:14]([O:16]C)=[O:15])=[CH:10][C:9]2=[O:18])[CH:5]=[CH:6][CH:7]=1.[Li+].[OH-]>O.CO>[F:1][C:2]1[CH:3]=[C:4]([N:8]2[CH:13]=[CH:12][C:11]([C:14]([OH:16])=[O:15])=[CH:10][C:9]2=[O:18])[CH:5]=[CH:6][CH:7]=1

Komponenten

5

Edukt 2

HCID 3939Lithium HydroxideHCID 68083398HCID 68083398, Verbindung

Produkt 1

HCID 680798531-(3-Fluorophenyl)-2-oxo-1,2-dihydropyridine-4-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

To a solution of methyl 1-(3-fluorophenyl)-2-oxo-1,2-dihydropyridine-4-carboxylate 89-2 (50 mg, 0.202 mmol) in water (0.5 mL) and methanol (0.5 mL) was added LiOH (20 mg, 0.835 mmol). After stirring at room temperature for 30 minutes, the mixture was concentrated with rotavap and the residue extracted with ethyl acetate, which was then evaporated to give crude 1-(3-fluorophenyl)-2-oxo-1,2-dihydropyridine-4-carboxylic acid 89-3.

Aufarbeitung

  1. concentrationthe mixture was concentrated with rotavap
  2. extractionthe residue extracted with ethyl acetate, which
  3. customwas then evaporated

Quellen und Nachweise

ORD-Eintrag
ord-5e497a2d71234e5a85617351badacf58
Quelldatensatz
uspto-grants-2015_11
Patentnummer
US09181235B2

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