Chlorosulfamic acid → HCID 67401501, Verbindung

Reaktionsgleichung

[NH2:1][C:2]1[S:6][C:5]2[C:7]3[C:12]([CH2:13][CH2:14][C:4]=2[C:3]=1[C:15]#[N:16])=[CH:11][CH:10]=[CH:9][CH:8]=3.[S:17](Cl)(=[O:20])(=[O:19])[NH2:18]>CC(N(C)C)=O.O>[S:17]([NH:1][C:2]1[S:6][C:5]2[C:7]3[C:12]([CH2:13][CH2:14][C:4]=2[C:3]=1[C:15]#[N:16])=[CH:11][CH:10]=[CH:9][CH:8]=3)(=[O:20])(=[O:19])[NH2:18]

Komponenten

Versuchsvorschrift

To a solution of 2-amino-4,5-dihydronaphtho[1,2-b]thiophene-3-carbonitrile (Example 93b) (250 mg, 1.11 mmol) in dimethylacetamide (5 mL) was added sulfamoyl chloride (385 mg, 3.33 mmol). The reaction mixture was stirred at room temperature under nitrogen for about 1 hr, then it was diluted with water and extracted with EtOAc, the organic layer was washed with brine, dried over Na2SO4, filtered and evaporated to give the crude product which was carried on for next step.