Hydrochloric Acid → 2-(4-(Methoxycarbonyl)-2-methylphenyl)acetic acid

HRID 714524Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 714524
C([O:3][C:4](=[O:17])[CH2:5][C:6]1[CH:15]=[CH:14][C:9]([C:10]([O:12][CH3:13])=[O:11])=[CH:8][C:7]=1[CH3:16])C.O.[Li+].[OH-].Cl>CO>[CH3:13][O:12][C:10]([C:9]1[CH:14]=[CH:15][C:6]([CH2:5][C:4]([OH:17])=[O:3])=[C:7]([CH3:16])[CH:8]=1)=[O:11]

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 3939Lithium HydroxideHCID 67365879Methyl 4-(2-ethoxy-2-oxoethyl)-3-methylbenzoate

Produkt 1

HCID 575552242-(4-(Methoxycarbonyl)-2-methylphenyl)acetic acidAusbeute 91,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Methyl 4-(2-ethoxy-2-oxoethyl)-3-methylbenzoate (366 mg) was suspended in MeOH(10 ml) and H2O (2 ml) and treated with LiOH (48 mg) over 3 days. After the reaction mixture was acidified with 1N HCl, the product was extracted with EtOAc. Evaporation and drying in vacuum afforded the desired product (295 mg).

Aufarbeitung

  1. extractionthe product was extracted with EtOAc
  2. customEvaporation
  3. customdrying in vacuum

Quellen und Nachweise

ORD-Eintrag
ord-13c55a5b75694ab0bd94317153354e56
Quelldatensatz
uspto-grants-2015_11
Patentnummer
US09187447B2

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