Acetic Acid → 2-(Methylthio)-1H-pyrimidin-4-one

HRID 714773

Reaktionsgleichung

Reaktionsgleichung von HRID 714773
[S:1]=[C:2]1[NH:7][C:6](=[O:8])[CH:5]=[CH:4][NH:3]1.[OH-].[Na+].[C:11](O)(=O)C>O.IC>[CH3:11][S:1][C:2]1[NH:7][C:6](=[O:8])[CH:5]=[CH:4][N:3]=1

Komponenten

6

Edukt 3

HCID 176Acetic AcidHCID 14798Sodium HydroxideHCID 1269845Thiouracil

Produkt 1

HCID 798232-(Methylthio)-1H-pyrimidin-4-one

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 6328Methyl iodideLösungsmittel

Versuchsvorschrift

To 2-thioxo-2,3-dihydropyrimidin-4(1H)-one (21 g) was added dropwise a solution of sodium hydroxide (13 g) in water (120 mL), iodomethane (11.5 mL) was added thereto, and the mixture was stirred overnight at room temperature. To the reaction mixture was added acetic acid (9.5 mL), and the resulting solid was collected by filtration. The obtained solid was washed with cold water to give the title compound (24 g).

Aufarbeitung

  1. additionwas added
  2. filtrationthe resulting solid was collected by filtration
  3. washThe obtained solid was washed with cold water

Quellen und Nachweise

ORD-Eintrag
ord-34b66474704041fea99a3a36c45d8f29
Quelldatensatz
uspto-grants-2015_11
Patentnummer
US09187453B2

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