Dimethylformamide → 2-Methyl-4-(N-ethyl-N-(beta-hydroxyethyl)amino)aniline

HRID 72080

Reaktionsgleichung

Reaktionsgleichung von HRID 72080
[CH3:1][CH2:2][N:3]([CH:7]([CH3:9])C)[CH:4]([CH3:6])[CH3:5].ClC(OCC1C=[CH:19][C:18]([N+:21]([O-])=O)=[CH:17][CH:16]=1)=O.CN(C)C=[O:27]>>[CH3:9][CH2:7][N:3]([C:4]1[CH:5]=[CH:19][C:18]([NH2:21])=[C:17]([CH3:16])[CH:6]=1)[CH2:2][CH2:1][OH:27]

Komponenten

4

Edukt 3

HCID 6228Dimethylformamide2×HCID 782054-Nitrobenzyl chloroformateHCID 81531Diisopropylethylamine

Produkt 1

HCID 753832-Methyl-4-(N-ethyl-N-(beta-hydroxyethyl)amino)aniline

Versuchsvorschrift

To 50 mg of Rho575 in dimethylformamide, 53 μl of N,N′-diisopropylethylamine was added followed by 78 mg of p-nitrobenzyl chloroformate dissolved in dimethylformamide. The reaction mixture was stirred for 3 days and the solvent was removed in vacuo. The residue was dissolved in chloroform and purified on a Biotage SP4 System with a SNAP 25 g column and a chloroform methanol gradient, to give a pink product.

Aufarbeitung

  1. customthe solvent was removed in vacuo
  2. dissolutionThe residue was dissolved in chloroform
  3. custompurified on a Biotage SP4 System with a SNAP 25 g column
  4. customa chloroform methanol gradient, to give a pink product

Quellen und Nachweise

ORD-Eintrag
ord-b9f955955cb84d719a000429b1b8dc1f
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08828678B2

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