Water → 2-bromo-N-(3-bromo-2-hydroxy-phenyl)-2-methyl-propionamide

HRID 723312Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 723312
N1C=CC=CC=1.[NH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([Br:14])[C:9]=1[OH:15].[Br:16][C:17]([CH3:22])([CH3:21])[C:18](Br)=[O:19].O>C(Cl)Cl>[Br:16][C:17]([CH3:22])([CH3:21])[C:18]([NH:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([Br:14])[C:9]=1[OH:15])=[O:19]

Komponenten

6

Edukt 4

HCID 962WaterHCID 1049PyridineHCID 886852-Bromo-2-methylpropionyl bromideHCID 155315062-Amino-6-bromophenol

Produkt 1

HCID 218735182-bromo-N-(3-bromo-2-hydroxy-phenyl)-2-methyl-propionamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

Pyridine (1.8 ml, 22.3 mmol) was added to a solution of 2-Amino-6-bromo-phenol (4.198 g, 22.3 mmol) in dry CH2Cl2 (200 ml). The mixture was cooled in ice and then a solution of 2-bromo-2-methyl-propionylbromide (2.8 ml, 22.6 mmol) was added slowly. The mixture was stirred at the room temperature for an hour and was poured into CH2Cl2 and water. The organic layer was washed with water, dried and concentrated in vacuo to yield crude 2-bromo-N-(3-bromo-2-hydroxy-phenyl)-2-methyl-propionamide, which was used directly in step 2.

Aufarbeitung

  1. temperatureThe mixture was cooled in ice
  2. washThe organic layer was washed with water
  3. customdried
  4. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-da887553a4e74faebce16e987dc52703
Quelldatensatz
uspto-grants-2006_11
Patentnummer
US07141562B2

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