Bromine → 6-Bromo-2-nitropyridin-3-ol

Temperatur

0 °C

3-Hydroxy-2-nitropyridine (20 g, 0.143 mole) was dissolved in methanol (400 ml) and a solution of 25% sodium methoxide in methanol (33 ml, 0.13 mole) was added at room temperature. The mixture was stirred for 30 min, then was cooled to 0° C., and bromine (7.2 ml, 0.14 mole) was added slowly. The reaction was then stirred at 0° C. for 30 min, then was quenched with glacial AcOH (2.5 ml). The solvent was removed in vacuo to afford material (30 g, 96%), which was used without further purification.

1. stirringThe reaction was then stirred at 0° C. for 30 min
2. customwas quenched with glacial AcOH (2.5 ml)
3. customThe solvent was removed in vacuo

ORD-Eintrag

ord-8e01353b988648b8b3ac93694dbe40d9

Quelldatensatz

uspto-grants-2006_11

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07141564B2