Benzene → 2,2-Dibutyl-4-hydroxy-1-indanone

HRID 727813Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 727813
[Si]([O:8][C:9]1[CH:17]=[CH:16][CH:15]=[C:14]2[C:10]=1[CH2:11][CH2:12][C:13]2=[O:18])(C(C)(C)C)(C)C.I[CH2:20][CH2:21][CH2:22][CH3:23].CC(C)([O-])C.[K+].O.[CH:31]1[CH:36]=CC=[CH:33][CH:32]=1>>[CH2:20]([C:12]1([CH2:36][CH2:31][CH2:32][CH3:33])[CH2:11][C:10]2[C:14](=[CH:15][CH:16]=[CH:17][C:9]=2[OH:8])[C:13]1=[O:18])[CH2:21][CH2:22][CH3:23]

Komponenten

6

Edukt 5

HCID 241BenzeneHCID 962WaterHCID 10962Butyl iodideHCID 158291994-{[tert-Butyl(dimethyl)silyl]oxy}-2,3-dihydro-1H-inden-1-oneHCID 23665647Potassium tert-butoxide

Produkt 1

HCID 106590162,2-Dibutyl-4-hydroxy-1-indanone

Versuchsvorschrift

A mixture of 4-(tert-butyldimethylsilyl)oxy-1-indanone (524 mg), 1-iodobutane (0.91 ml), and potassium tert-butoxide (896 mg) in dry benzene (15 ml) was refluxed for 2 hours under nitrogen. The reaction mixture was allowed to cool and poured into water. The separated oil was extracted with ethyl acetate. The organic layer was washed with brine, and concentrated in vacuo. The residue was subjected to column-chromatography on silica gel (elution by 10% n-hexane in dichloromethane and then dichloromethane) to yield 2,2-dibutyl-4-hydroxy-1-indanone (150 mg) as crystals.

Aufarbeitung

  1. temperaturewas refluxed for 2 hours under nitrogen
  2. temperatureto cool
  3. extractionThe separated oil was extracted with ethyl acetate
  4. washThe organic layer was washed with brine
  5. concentrationconcentrated in vacuo
  6. washelution by 10% n-hexane in dichloromethane

Quellen und Nachweise

ORD-Eintrag
ord-1cffa1623f8c430596a323d79f0bda9f
Quelldatensatz
uspto-grants-1991_09
Patentnummer
US05045548

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