Acetic Acid → Ethyl 3-amino-3-[1-(4-chlorophenyl)cyclobutyl]propanoate

HRID 728280Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 728280
[NH2:1][C:2]([C:9]1([C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=2)[CH2:12][CH2:11][CH2:10]1)=[CH:3][C:4]([O:6][CH2:7][CH3:8])=[O:5].C([BH3-])#N.[Na+].C([O-])(=O)C.[NH4+].C(O)(=O)C>C(O)C>[NH2:1][CH:2]([C:9]1([C:13]2[CH:14]=[CH:15][C:16]([Cl:19])=[CH:17][CH:18]=2)[CH2:10][CH2:11][CH2:12]1)[CH2:3][C:4]([O:6][CH2:7][CH3:8])=[O:5]

Komponenten

6

Edukt 4

HCID 176Acetic AcidHCID 517165Ammonium AcetateHCID 5003444Sodium cyanoborohydrideHCID 67945594Ethyl 3-amino-3-[1-(4-chlorophenyl)cyclobutyl]acrylate

Produkt 1

HCID 19823680Ethyl 3-amino-3-[1-(4-chlorophenyl)cyclobutyl]propanoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of ethyl 3-amino-3-[1-(4-chlorophenyl)-cyclobutyl]acrylate (90 g), sodium cyanoborohydride (36 g), ammonium acetate (27 g) and acetic acid (60 ml) in ethanol (1.5 litres) was allowed to stand at room temperature for 5 days and then concentrated to 600 ml and poured into water (2.5 litres). The aqueous solution was basified, extracted with ether and the ether extract back extracted with 2N hydrochloric acid. The acidic aqueous extract was cooled with ice, basified and extracted with ether and the extract dried and evaporated to give ethyl 3-amino-3-[1-(4-chlorophenyl)cyclobutyl]propanoate.

Aufarbeitung

  1. concentrationconcentrated to 600 ml
  2. additionpoured into water (2.5 litres)
  3. extractionextracted with ether
  4. extractionthe ether extract back
  5. extractionextracted with 2N hydrochloric acid
  6. extractionThe acidic aqueous extract
  7. temperaturewas cooled with ice
  8. extractionextracted with ether
  9. customthe extract dried
  10. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-8d5fbb128b3743be8ba0ecd4b8913597
Quelldatensatz
uspto-grants-1991_09
Patentnummer
US05047432

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