4,4'-Difluorobenzophenone → N-[Bis(4-fluorophenyl)methyl]formamide

HRID 730429Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 730429
[F:1][C:2]1[CH:16]=[CH:15][C:5]([C:6]([C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=2)=O)=[CH:4][CH:3]=1.[CH:17]([O-:19])=O.[NH4+:20]>O>[F:1][C:2]1[CH:16]=[CH:15][C:5]([CH:6]([NH:20][CH:17]=[O:19])[C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 95824,4'-DifluorobenzophenoneHCID 2723923Ammonium formate

Produkt 1

HCID 25126459N-[Bis(4-fluorophenyl)methyl]formamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
170 °C

Versuchsvorschrift

A mixture of 4,4′-difluorobenzophenone (15.0 g, 68.7 mmol) and ammonium formate (35.3 g, 559 mmol) was stirred at 170° C. for 10 hours. The reaction solution was poured into water and extracted with ethyl acetate. The extract was washed with water, dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure to give the objective product as a solid material.

Aufarbeitung

  1. extractionextracted with ethyl acetate
  2. washThe extract was washed with water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. distillationthe solvent was distilled off under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-eb2c72aa499245f4bd326ccde6b7d88e
Quelldatensatz
uspto-grants-2009_09
Patentnummer
US07582651B2

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