Acetic Acid → Dimethyl-(6-trifluoromethyl-1H-indol-5-yl)amine

HRID 73349Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 73349
[CH3:1][N:2]([CH3:19])[C:3]1[C:4]([C:15]([F:18])([F:17])[F:16])=[CH:5][C:6]([N+:12]([O-])=O)=[C:7]([CH2:9][C:10]#N)[CH:8]=1.C(O)C.C(O)(=O)C>[C].[Pd].O>[CH3:1][N:2]([CH3:19])[C:3]1[CH:8]=[C:7]2[C:6](=[CH:5][C:4]=1[C:15]([F:18])([F:17])[F:16])[NH:12][CH:10]=[CH:9]2

Komponenten

6

Edukt 3

HCID 176Acetic AcidHCID 702EthanolHCID 58437521(5-Dimethylamino-2-nitro-4-trifluoromethylphenyl)acetonitrile

Produkt 1

HCID 58437283Dimethyl-(6-trifluoromethyl-1H-indol-5-yl)amineAusbeute 119,7 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
35 °C

Versuchsvorschrift

To a solution of (5-dimethylamino-2-nitro-4-trifluoromethylphenyl)acetonitrile (0.058 g) in a mixed solvent of ethanol (1 mL), acetic acid (0.1 mL) and water (0.1 mL) was added palladium-carbon powder (0.0058 g), and this mixture was stirred at 35° C. for 16 hours. The insoluble material was removed by filtration and the filtrate was concentrated under reduced pressure to give the title compound (0.058 g).

Aufarbeitung

  1. customThe insoluble material was removed by filtration
  2. concentrationthe filtrate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-7f6d2e868f7e4143bf413ee27e8a8cc8
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08829040B2

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