Bromine → 2-Amino-3-bromo-5-methylbenzoic acid

HRID 734484

Reaktionsgleichung

Reaktionsgleichung von HRID 734484
[NH2:1][C:2]1[CH:10]=[CH:9][C:8]([CH3:11])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[Br:12]Br>C(O)(=O)C>[NH2:1][C:2]1[C:10]([Br:12])=[CH:9][C:8]([CH3:11])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

Komponenten

4

Edukt 2

HCID 24408BromineHCID 762552-Amino-5-methylbenzoic acid

Produkt 1

HCID 27744002-Amino-3-bromo-5-methylbenzoic acidAusbeute 85,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

To a solution of 2-amino-5-methylbenzoic acid (25.0 g, 170 mmol) in acetic acid (250 ml) was added bromine (10 ml, 195 mmol) and the reaction mixture was stirred at room temperature for 2 h. The mixture was filtered and the solid material was washed with water and cyclohexane and dried to give the title compound (33.4 g).

Aufarbeitung

  1. filtrationThe mixture was filtered
  2. washthe solid material was washed with water and cyclohexane
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-d082f7436bc94d3ea57c5f9be967b285
Quelldatensatz
uspto-grants-2009_09
Patentnummer
US07592362B2

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