Sodium Hydroxide → HCID 13251820, Verbindung

HRID 745484

Reaktionsgleichung

Reaktionsgleichung von HRID 745484
[NH2:1][C@@H:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C@H:3]1[NH2:8].[C:9]([C:13]1[CH:18]=[CH:17][C:16]([CH2:19][CH:20]([CH3:23])[CH2:21]Cl)=[CH:15][CH:14]=1)([CH3:12])([CH3:11])[CH3:10].[OH-].[Na+]>CCOCC>[C:9]([C:13]1[CH:14]=[CH:15][C:16]([CH2:19][CH:20]([CH3:23])[CH2:21][NH:1][C@@H:2]2[CH2:7][CH2:6][CH2:5][CH2:4][C@H:3]2[NH2:8])=[CH:17][CH:18]=1)([CH3:12])([CH3:11])[CH3:10]

Komponenten

5

Edukt 3

HCID 14798Sodium HydroxideHCID 438061,2-Diaminocyclohexane, trans-HCID 132518171-tert-Butyl-4-(3-chloro-2-methylpropyl)benzene

Produkt 1

HCID 13251820HCID 13251820, VerbindungAusbeute 83,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Reaktionsbedingungen

Temperatur
140 °C

Versuchsvorschrift

274 g of trans-1,2-diaminocyclohexane and 134.4 g of 3-(4-tert.-butylphenyl)-2-methylpropyl chloride (German Laid-Open Application DOS No. 2,752,096) were stirred for 10 hours at 140° C. and then cooled to +10° C. in an ice bath, and 200 ml of a 50% strength by weight sodium hydroxide solution were added slowly, followed by the addition of 200 ml of ether. The organic phase was separated off, dried over potassium hydroxide and distilled to give 151 g of N-(3-(4-tert.-butylphenyl)-2-methylpropyl)-trans-1,2-diaminocyclohexane of boiling point 175°-180° C./0.3 mbar. Yield: 83.3% of theory.

Aufarbeitung

  1. temperaturecooled to +10° C. in an ice bath
  2. customThe organic phase was separated off
  3. dry with materialdried over potassium hydroxide
  4. distillationdistilled

Quellen und Nachweise

ORD-Eintrag
ord-9d6febe3472e4acb8c5384b0ade92637
Quelldatensatz
uspto-grants-1986_07
Patentnummer
US04599335

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