Water → Ethyl 6-[4-(2-oxo-1,2-dihydro-quinolin-3-yl)-piperidin-1-yl]-pyrimidine-4-carboxylate

HRID 74559Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 74559
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH:3]=1.[NH:13]1[CH2:18][CH2:17][CH:16]([C:19]2[CH:20]([OH:29])[NH:21][C:22]3[C:27]([CH:28]=2)=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH2:15][CH2:14]1.CCN(C(C)C)C(C)C.O>CN(C=O)C>[O:29]=[C:20]1[C:19]([CH:16]2[CH2:17][CH2:18][N:13]([C:2]3[N:7]=[CH:6][N:5]=[C:4]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH:3]=3)[CH2:14][CH2:15]2)=[CH:28][C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[NH:21]1

Komponenten

6

Edukt 4

HCID 962WaterHCID 81531DiisopropylethylamineHCID 22756838Ethyl 6-chloropyrimidine-4-carboxylateHCID 673376243-Piperidin-4-yl-1,2-dihydro-quinolin-2-ol

Produkt 1

HCID 58386736Ethyl 6-[4-(2-oxo-1,2-dihydro-quinolin-3-yl)-piperidin-1-yl]-pyrimidine-4-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

730 mg (3.91 mmol) ethyl 6-chloropyrimidine-4-carboxylate were placed in 10 mL DMF. 900 mg (3.94 mmol) 3-piperidin-4-yl-1,2-dihydro-quinolin-2-ol and 2.30 mL (13.4 mmol) DIPEA were added and the reaction mixture was stirred overnight at RT. The reaction mixture was mixed with 60 mL water and stirred for 30 min. The precipitated solid was suction filtered and dried.

Aufarbeitung

  1. stirringstirred for 30 min
  2. filtrationfiltered
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-2af5a626b26641d5b8965c6ccdce442c
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08829006B2

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