Sodium Hydroxide → 6-fluoro-2,3-dihydro-1H-indole
Reaktionsgleichung
C([BH3-])#N.[Na+].[F:5][C:6]1[CH:14]=[C:13]2[C:9]([CH:10]=[CH:11][NH:12]2)=[CH:8][CH:7]=1.[OH-].[Na+]>C(O)(=O)C>[F:5][C:6]1[CH:14]=[C:13]2[C:9]([CH2:10][CH2:11][NH:12]2)=[CH:8][CH:7]=1Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
Under a nitrogen atmosphere 0.29 g (4.6 mmol) sodium cyanoborohydride were added batchwise to 0.54 g (4.0 mmol) 6-fluoroindole in 5.0 mL glacial acetic acid and the mixture was stirred for 30 min. Then the reaction mixture was poured onto a 4N aqueous sodium hydroxide solution and extracted with EtOAc. The combined organic phases were washed several times with saturated sodium hydrogen carbonate solution, dried on sodium sulphate and evaporated down.
Aufarbeitung
- extractionextracted with EtOAc
- washThe combined organic phases were washed several times with saturated sodium hydrogen carbonate solution
- customdried on sodium sulphate
- customevaporated down
Quellen und Nachweise
- ORD-Eintrag
- ord-5be21d4c530342cc93a44e37b2e1b052
- Quelldatensatz
- uspto-grants-2014_09
- Patentnummer
- US08829006B2
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