Water → 2-(Morpholin-4-yl)pyridine-4-carbonitrile

HRID 748139Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 748139
Cl[C:2]1[CH:7]=[C:6]([C:8]#[N:9])[CH:5]=[CH:4][N:3]=1.[NH:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1.O>CN1CCCC1=O>[N:10]1([C:2]2[CH:7]=[C:6]([CH:5]=[CH:4][N:3]=2)[C:8]#[N:9])[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1

Komponenten

5

Edukt 3

HCID 962WaterHCID 8083MorpholineHCID 5686382-Chloro-4-cyanopyridine

Produkt 1

HCID 146408562-(Morpholin-4-yl)pyridine-4-carbonitrileAusbeute 71,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 13387N-methyl-2-pyrrolidoneLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

2-Chloro-4-cyanopyridine (0.40 g, 2.9 mmol) was dissolved in N-methylpyrrolidone (2.0 ml), and morpholine (0.7 ml, 8.0 mmol) was added thereto. The reaction mixture was stirred at 100° C. for 2.5 hrs and combined with water to give precipitates, which were collected by filtration and dried to give the titled compound (0.39 g, 70%).

Aufarbeitung

  1. customto give
  2. customprecipitates
  3. filtrationwhich were collected by filtration
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-c0f0421c3ce347788ef8f699a2883eca
Quelldatensatz
uspto-grants-2008_07
Patentnummer
US07399759B2

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