Ammonium Hydroxide → 2-Amino-1-methylcyclohexan-1-ol

HRID 74943

Reaktionsgleichung

Reaktionsgleichung von HRID 74943
[CH3:1][C:2]12[O:8][CH:7]1[CH2:6][CH2:5][CH2:4][CH2:3]2.[OH-].[NH4+:10]>O>[NH2:10][CH:7]1[CH2:6][CH2:5][CH2:4][CH2:3][C:2]1([CH3:1])[OH:8]

Komponenten

4

Edukt 2

HCID 14923Ammonium HydroxideHCID 2242431-Methyl-1,2-epoxycyclohexane2×

Produkt 1

HCID 203650302-Amino-1-methylcyclohexan-1-ol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel2×

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

To a solution of 1-methyl-7-oxabicyclo[4.1.0]heptane, 30a, (1.0 g, 7.1 mmol) in water was added ammonium hydroxide (6.0 mL, 154.1 mmol). The mixture was heated to 50° C. for 48 hours. The mixture was diluted with water, extracted with EtOAc and then twice with 20% MeOH/CHCl3. The organic phases were dried (MgSO4), filtered and concentrated in vacuo to provide the desired product, 30b, as an amorphous white solid.

Aufarbeitung

  1. extractionextracted with EtOAc
  2. dry with materialThe organic phases were dried (MgSO4)
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-0e1f6b80027642ee843f29d90f473c6d
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08829007B2

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