Iodoethane → 3,5-Dichlorophenyl ethyl sulfide

HRID 75230

Reaktionsgleichung

Reaktionsgleichung von HRID 75230
[Cl:1][C:2]1[CH:3]=[C:4]([SH:9])[CH:5]=[C:6]([Cl:8])[CH:7]=1.I[CH2:11][CH3:12].C(=O)([O-])[O-].[K+].[K+].C(Cl)Cl>O>[CH2:11]([S:9][C:4]1[CH:3]=[C:2]([Cl:1])[CH:7]=[C:6]([Cl:8])[CH:5]=1)[CH3:12]

Komponenten

6

Edukt 4

HCID 6340IodoethaneHCID 6344DichloromethaneHCID 11430Potassium CarbonateHCID 27360963,5-Dichlorobenzenethiol

Produkt 1

HCID 597520583,5-Dichlorophenyl ethyl sulfideAusbeute 97,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A solution of 3,5-dichlorobenzenethiol (1.50 g, 8.4 mmol), iodoethane (1.34 mL, 16.8 mmol), potassium carbonate (1.74 g, 12.6 mmol) and methylene chloride (10 mL) was stirred at 25° C. for 30 minutes. The reaction was diluted with water and extracted with ethyl acetate three times, dried over sodium sulfate, filtered and concentrated. The residue was purified by chromatography on silica gel to give the desired product (1.69 g, 97%). LC/MS: 207 (M+H)+.

Aufarbeitung

  1. extractionextracted with ethyl acetate three times
  2. dry with materialdried over sodium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated
  5. customThe residue was purified by chromatography on silica gel

Quellen und Nachweise

ORD-Eintrag
ord-9402da52b7b946efb3caf5900f1f5e5b
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08835423B2

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