Acetyl chloride → HCID 178419044, Verbindung

HRID 7524

Reaktionsgleichung

Reaktionsgleichung von HRID 7524
[NH2:1][C:2]1[CH:7]=[N:6][CH:5]=[CH:4][N:3]=1.[CH:8]1([N+:14]#[C-:15])[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1.[N:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[CH:22]=O.[C:24]([Cl:27])(=[O:26])[CH3:25]>Cl(O)(=O)(=O)=O>[Cl-:27].[C:24]([N+:1]1[C:22]([C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][N:16]=2)=[C:15]([NH:14][CH:8]2[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]2)[N:3]2[CH:4]=[CH:5][N:6]=[CH:7][C:2]=12)(=[O:26])[CH3:25]

Komponenten

6

Edukt 4

HCID 6367Acetyl chlorideHCID 142732-PyridinecarboxaldehydeHCID 78747AminopyrazineHCID 79129Cyclohexyl isocyanide

Produkt 1

HCID 178419044HCID 178419044, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 24247Perchloric AcidLösungsmittel

Versuchsvorschrift

Example 18 was carried out in accordance with the general directions for synthesis in process step a) from 1.0 ml (0.1 mmol) 2-amino-pyrazine (0.1 M, DCM), 0.575 ml (0.115 mmol) cyclohexylisonitrile solution (0.2 M, DCM), 0.500 ml (0.15 mmol) pyridine-2-carbaldehyde solution (0.3 M, DCM) and 10 μl perchloric acid (w=20%) and in process step c) and d) by reacting the resultant reaction product with 0.4 mmol acetylchloride.

Quellen und Nachweise

ORD-Eintrag
ord-a7f6f74d3a9f43fa8b7eb8ec0624032a
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07087607B2

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