N,O-Dimethylhydroxylamine → 5-bromo-N,2-dimethoxy-N-methylnicotinamide
Reaktionsgleichung
CNOC.COc1ncc(Br)cc1C(=O)O.COC1=NC(=NC(=N1)Cl)Cl.CN1CCOCC1.CN(C)C=O>>COc1ncc(Br)cc1C(=O)N(C)OCKomponenten
6
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 3
Reaktionsbedingungen
- Temperatur
- 25 °C
Aufarbeitung
- addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
- addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
- aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
- addition380 uL MeCN solvent were added to the transfer plate
- aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
- addition180 uL MeCN added to filter plate 1 for LCMS analysis
- aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
- addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
- customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM
Quellen und Nachweise
- ORD-Eintrag
- ord-44947da9a4e2495f8fcc743a48b3cd7b
- Quelldatensatz
- AIChemEco amide coupling conditions 47k dataset
Notizen zur Reaktion
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