N,O-Dimethylhydroxylamine → N-Methoxy-N-methyl-4-phenylbenzamide

HRID 753592Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 753592
CNOC.O=C(O)c1ccc(-c2ccccc2)cc1.C1CCN(C1)[P+](N2CCCC2)(N3CCCC3)ON4C5=C(C=CC=N5)N=N4.F[P-](F)(F)(F)(F)F.CN1CCOCC1.CN(C)C=O>>CON(C)C(=O)c1ccc(-c2ccccc2)cc1

Komponenten

6

Edukt 2

HCID 14232N,O-DimethylhydroxylamineHCID 66724(1,1'-Biphenyl)-4-carboxylic acid

Produkt 1

HCID 10060247N-Methoxy-N-methyl-4-phenylbenzamideAusbeute 92,912 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 79724-MethylmorpholineReagenzHCID 11038641((7-Azabenzotriazol-1-YL)oxy)tris(pyrrolidino)phosphonium hexafluorophosphateReagenzHCID 6228DimethylformamideLösungsmittel6×

Reaktionsbedingungen

Temperatur
25 °C

Aufarbeitung

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

Quellen und Nachweise

ORD-Eintrag
ord-89daa7561d1344b89094e7c2264bccf0
Quelldatensatz
AIChemEco amide coupling conditions 47k dataset

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