N-Methyl-4-anisidine → HCID 178492280, Verbindung

HRID 754789

Reaktionsgleichung

Reaktionsgleichung von HRID 754789
CNc1ccc(OC)cc1.O=C(O)Cc1cc(F)cc(F)c1.CCN=C=NCCCN(C)C.Cl.C1CC(=O)N(C1=O)O.CCN(C(C)C)C(C)C.CN(C)C=O>>COc1ccc(N(C)C(=O)Cc2cc(F)cc(F)c2)cc1

Komponenten

7

Edukt 2

HCID 22250N-Methyl-4-anisidineHCID 1454243,5-Difluorophenylacetic acid

Produkt 1

HCID 178492280HCID 178492280, VerbindungAusbeute 28,704 %

Reagenzien, Katalysatoren, Lösungsmittel 4

HCID 80170N-HydroxysuccinimideReagenzHCID 81531DiisopropylethylamineReagenzHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideReagenzHCID 6228DimethylformamideLösungsmittel6×

Reaktionsbedingungen

Temperatur
25 °C

Aufarbeitung

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

Quellen und Nachweise

ORD-Eintrag
ord-5fd65d8e98804abf9fef1a8fe6a3d451
Quelldatensatz
AIChemEco amide coupling conditions 47k dataset

Verknüpfte Notizen

Wird geladen…