Cyclopentylamine → (E)-Ethyl 2-acetamido-3-(cyclopentylamino)but-2-enoate

HRID 75495

Reaktionsgleichung

Reaktionsgleichung von HRID 75495
[C:1]([NH:4]/[C:5](=[C:11](/[N:13]([CH3:15])C)\[CH3:12])/[C:6]([O:8][CH2:9][CH3:10])=[O:7])(=[O:3])[CH3:2].[CH:16]1(N)[CH2:20]C[CH2:18][CH2:17]1>CC(O)=O.O>[C:1]([NH:4]/[C:5](=[C:11](/[NH:13][CH:15]1[CH2:18][CH2:17][CH2:16][CH2:20]1)\[CH3:12])/[C:6]([O:8][CH2:9][CH3:10])=[O:7])(=[O:3])[CH3:2]

Komponenten

5

Edukt 2

HCID 2906CyclopentylamineHCID 54579441(E)-ethyl 2-acetamido-3-(dimethylamino)but-2-enoate2×

Produkt 1

HCID 54579442(E)-Ethyl 2-acetamido-3-(cyclopentylamino)but-2-enoate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 176Acetic AcidLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

(E)-ethyl 2-acetamido-3-(dimethylamino)but-2-enoate (compound 16, 1 g, 4.67 mmol) and cyclopentylamine (0.5 mL) were stirred at room temperature in AcOH (10 mL) for overnight. The reaction mixture was diluted slowly with water (10 mL) and evaporated under reduced pressure to obtain the desired product as a dark brown oil, which could be used without any further purification for the next step.

Aufarbeitung

  1. customevaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-f21a1bee4a0f4c51879b70c98fcafeea
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08835436B2

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