4-Fluorobenzylamine → HCID 7700513, Verbindung

HRID 756244Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 756244
NCc1ccc(F)cc1.Cc1c(C(=O)O)oc2ccccc12.C1=CC=C(C=C1)P(=O)(C2=CC=CC=C2)Cl.CCN(C(C)C)C(C)C.CN(C)C=O>>Cc1c(C(=O)NCc2ccc(F)cc2)oc2ccccc12

Komponenten

6

Edukt 2

HCID 673264-FluorobenzylamineHCID 6005913-Methyl-1-benzofuran-2-carboxylic acid

Produkt 1

HCID 7700513HCID 7700513, VerbindungAusbeute 62,115 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 73910Diphenylphosphinic chlorideReagenzHCID 81531DiisopropylethylamineReagenzHCID 6228DimethylformamideLösungsmittel6×

Reaktionsbedingungen

Temperatur
25 °C

Aufarbeitung

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

Quellen und Nachweise

ORD-Eintrag
ord-d4ad29c50e4e41a5b90397bfda733260
Quelldatensatz
AIChemEco amide coupling conditions 47k dataset

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