Pyridine → (R)-tert-butyl 1-cyanoethylcarbamate

HRID 77123

Reaktionsgleichung

Reaktionsgleichung von HRID 77123
[NH2:1][C:2](=O)[C@H:3]([NH:5][C:6](=[O:12])[O:7][C:8]([CH3:11])([CH3:10])[CH3:9])[CH3:4].CC1C=CC(S(Cl)(=O)=O)=CC=1.N1C=CC=CC=1.C(OC(=O)C)(=O)C>C(Cl)Cl>[C:2]([C@H:3]([NH:5][C:6](=[O:12])[O:7][C:8]([CH3:11])([CH3:10])[CH3:9])[CH3:4])#[N:1]

Komponenten

6

Edukt 4

HCID 1049PyridineHCID 73974-Toluenesulfonyl chlorideHCID 7918Acetic AnhydrideHCID 7015296Boc-D-Ala-NH2

Produkt 1

HCID 5479028(R)-tert-butyl 1-cyanoethylcarbamateAusbeute 37,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of (R)-tert-butyl 1-amino-1-oxopropan-2-ylcarbamate (Int-X-A, 1 g, 5.31 mmol) and 4-methylbenzene-1-sulfonyl chloride (4.05 g, 21.25 mmol) in CH2Cl2 (5 mL) was added pyridine (2.101 g, 26.6 mmol). After 3 h, acetic anhydride (0.651 g, 6.38 mmol) was added. This was stirred overnight before it was concentrated and EtOAc was added. Saturated NaHCO3 was added and the two phase mixture was stirred vigorously for 2 h. The organic layer was washed with 1 N HCl and then saturated NaHCO3. The organic layer was dried and concentrated. The resulting residue was purified by flash chromatography (Isco Combiflash Companion, 40 g silica gel, 15% ethyl acetate-hexane) to provide the product (R)-tert-butyl 1-cyanoethylcarbamate (Int-X-B, 336 mg, 1.974 mmol, 37.2% yield); [M+Na]+=193.2; 1H NMR (400 MHz, methanol-d4) δ ppm 4.51 (1 H, q), 1.34-1.58 (12 H, m).

Aufarbeitung

  1. concentrationwas concentrated
  2. additionEtOAc was added
  3. additionSaturated NaHCO3 was added
  4. stirringthe two phase mixture was stirred vigorously for 2 h
  5. washThe organic layer was washed with 1 N HCl
  6. customThe organic layer was dried
  7. concentrationconcentrated
  8. customThe resulting residue was purified by flash chromatography (Isco Combiflash Companion, 40 g silica gel, 15% ethyl acetate-hexane)

Quellen und Nachweise

ORD-Eintrag
ord-e084edfba7704cc5bcdd40a16f9c1ce3
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08835470B2

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