Allyl bromide → 3-allyl-4,5-dimethylthiazol-2(3H)-imine hydrobromide

HRID 78488

Reaktionsgleichung

Reaktionsgleichung von HRID 78488
[CH3:1][C:2]1[N:3]=[C:4]([NH2:8])[S:5][C:6]=1[CH3:7].[CH2:9]([Br:12])[CH:10]=[CH2:11]>C1(C)C=CC=CC=1.CCOCC>[BrH:12].[CH2:11]([N:3]1[C:2]([CH3:1])=[C:6]([CH3:7])[S:5][C:4]1=[NH:8])[CH:10]=[CH2:9]

Komponenten

5

Edukt 2

HCID 7841Allyl bromideHCID 732382-Amino-4,5-dimethyl-1,3-thiazole

Produkt 1

HCID 686235423-allyl-4,5-dimethylthiazol-2(3H)-imine hydrobromide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 1140TolueneLösungsmittelHCID 3283Diethyl EtherLösungsmittel

Reaktionsbedingungen

Temperatur
85 °C

Versuchsvorschrift

A mixture of 4,5-dimethyl-1,3-thiazol-2-amine (1 g) and allylbromide (0.95 g) in toluene (5 mL) was heated to 85° C. for 12 hours, cooled, diluted with ether, filtered and the solvent was evaporated to afford crude product that was taken on to the next step without further characterization.

Aufarbeitung

  1. temperaturecooled
  2. filtrationfiltered
  3. customthe solvent was evaporated
  4. customto afford crude product that

Quellen und Nachweise

ORD-Eintrag
ord-b550bf94e1dc44afbb8ef0c33f28bdba
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08841334B2

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