Hydrochloric Acid → Lithium 7-(2-(4-isopropylpiperazin-1-yl)ethoxy)imidazo[1,2-a]pyridine-3-carboxylate

HRID 79391

Reaktionsgleichung

Reaktionsgleichung von HRID 79391
[CH:1]([N:4]1[CH2:9][CH2:8][N:7]([CH2:10][CH2:11][O:12][C:13]2[CH:18]=[CH:17][N:16]3[C:19]([C:22]([O:24]CC)=[O:23])=[CH:20][N:21]=[C:15]3[CH:14]=2)[CH2:6][CH2:5]1)([CH3:3])[CH3:2].O.[OH-].[Li+:29].Cl>O>[CH:1]([N:4]1[CH2:9][CH2:8][N:7]([CH2:10][CH2:11][O:12][C:13]2[CH:18]=[CH:17][N:16]3[C:19]([C:22]([O-:24])=[O:23])=[CH:20][N:21]=[C:15]3[CH:14]=2)[CH2:6][CH2:5]1)([CH3:3])[CH3:2].[Li+:29]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 168937Lithium hydroxide, monohydrateHCID 67260889Ethyl 7-(2-(4-isopropylpiperazin-1-yl)ethoxy)imidazo[1,2-a]pyridine-3-carboxylate

Produkt 1

HCID 67260109Lithium 7-(2-(4-isopropylpiperazin-1-yl)ethoxy)imidazo[1,2-a]pyridine-3-carboxylateAusbeute 101,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
95 °C

Versuchsvorschrift

To ethyl 7-(2-(4-isopropylpiperazin-1-yl)ethoxy)imidazo[1,2-a]pyridine-3-carboxylate (5.68 g, 15.8 mmol) in H2O (30 mL) was added lithium hydroxide hydrate (0.67 g, 16.0 mmol). The reaction mixture was heated to 95° C. for 4 hours. The mixture was cooled to ambient temperature and hydrogen chloride (0.0394 mL, 4M in dioxane) was added. The mixture was stirred for 10 minutes. The H2O was removed under reduced pressure and the residue placed under high vacuum for 16 hours to give the product (5.43 g).

Aufarbeitung

  1. temperatureThe mixture was cooled to ambient temperature
  2. customThe H2O was removed under reduced pressure
  3. waitthe residue placed under high vacuum for 16 hours

Quellen und Nachweise

ORD-Eintrag
ord-dbb59f431023474cb17ee657448e9426
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08841455B2

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