Sodium Carbonate → (3-Amino-6-bromo-pyrazin-2-yl)-pyridin-3-yl-methanone

HRID 81474

Reaktionsgleichung

Reaktionsgleichung von HRID 81474
[NH2:1][C:2]1[C:3]([C:8]([C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)=[O:9])=[N:4][CH:5]=[CH:6][N:7]=1.C([O-])([O-])=O.[Na+].[Na+].[Br:22]Br>C(O)(=O)C>[NH2:1][C:2]1[C:3]([C:8]([C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)=[O:9])=[N:4][C:5]([Br:22])=[CH:6][N:7]=1

Komponenten

5

Edukt 3

HCID 10340Sodium Carbonate2×HCID 24408Bromine2×HCID 68630652(3-Amino-pyrazin-2-yl)-pyridin-3-yl-methanone

Produkt 1

HCID 86634541(3-Amino-6-bromo-pyrazin-2-yl)-pyridin-3-yl-methanone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel3×

Versuchsvorschrift

(3-Amino-pyrazin-2-yl)-pyridin-3-yl-methanone (1.00 g, 4.99 mmol) is dissolved in glacial acetic acid (10 ml). Na2CO3 (0.583 g, 5.49 mmol) is added. After evolution of gas has finished, a solution of bromine (0.192 ml, 3.74 mmol) in acetic acid (5 ml) is added dropwise. Na2CO3 (0.583 mg, 5.49 mmol) is added, followed by a second solution of bromine (0.192 ml, 3.74 mmol) in acetic acid (5 ml). The resulting orange suspension is left to stir for 1 hour. The reaction is quenched by pouring onto ice water (150 ml), and the orange solid formed is collected by filtration, washed with water and dried in vacuo at 40° C. overnight to yield the title compound. [M+H]+ 279.

Aufarbeitung

  1. waitThe resulting orange suspension is left
  2. customThe reaction is quenched
  3. additionby pouring onto ice water (150 ml)
  4. customthe orange solid formed
  5. filtrationis collected by filtration
  6. washwashed with water
  7. customdried in vacuo at 40° C. overnight

Quellen und Nachweise

ORD-Eintrag
ord-2df8dadc6d6444069182564d5bc89b78
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08846687B2

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