Pyridine → Ethanone, 2-(acetyloxy)-1-phenyl-

HRID 8191

Reaktionsgleichung

Reaktionsgleichung von HRID 8191
[OH:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:4].N1C=CC=CC=1.[C:17](OC(=O)C)(=[O:19])[CH3:18]>CN(C)C1C=CN=CC=1.ClCCl>[O:4]=[C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[CH2:2][O:1][C:17](=[O:19])[CH3:18]

Komponenten

6

Edukt 3

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 68490alpha-Hydroxyacetophenone

Produkt 1

HCID 222851Ethanone, 2-(acetyloxy)-1-phenyl-

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 142844-(Dimethylamino)pyridineKatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A solution of 2-hydroxyaceto-phenone (10 g, 73.4 mmol), pyridine (17.4 g, 220.2 mmol), dichloromethane (734 mL), 3 crystals of 4-dimethylaminopyridine is cooled to −78° C. To this solution is added acetic anhydride (13.9 mL, 146.9 mmol) then warmed to room temperature and stirred for 18 h. The mixture is washed with water (200 mL) and brine (200 mL) then dried over sodium sulfate. The mixture is filtered and concentrated in vacuo to yield the title compound, 13 g (99%), as a colorless liquid.

Aufarbeitung

  1. washThe mixture is washed with water (200 mL) and brine (200 mL)
  2. dry with materialthen dried over sodium sulfate
  3. filtrationThe mixture is filtered
  4. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-0a2ba70e58064169870e248f2da8307c
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07087626B2

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