Acetic Acid → ethyl 6-oxo-1,2-dihydropyrazolo[3,4-b]pyridine-4-carboxylate

HRID 82020

Reaktionsgleichung

Reaktionsgleichung von HRID 82020
[NH2:1][C:2]1[CH:6]=[CH:5][NH:4][N:3]=1.[Na].[C:8](OCC)(=[O:17])[CH2:9][C:10]([C:12]([O:14][CH2:15][CH3:16])=[O:13])=O.C(O)(=O)C>O>[CH2:15]([O:14][C:12]([C:10]1[C:6]2[CH:5]=[N:4][NH:3][C:2]=2[N:1]=[C:8]([OH:17])[CH:9]=1)=[O:13])[CH3:16]

Komponenten

5

Edukt 3

HCID 176Acetic AcidHCID 57351814Diethyl 2-oxosuccinate,sodium saltHCID 178418806HCID 178418806, Verbindung

Produkt 1

HCID 178469358ethyl 6-oxo-1,2-dihydropyrazolo[3,4-b]pyridine-4-carboxylateAusbeute 28,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel2×

Reaktionsbedingungen

Temperatur
85 °C

Versuchsvorschrift

To a solution of 3-aminopyrazole (224 g, 2.7 mol) in water (1 L) were added a solution of diethyl oxalacetate sodium salt (567 g, 2.7 mol) in water (1.3 L) and then acetic acid in 4 portions (0.8 L). The reaction mixture was heated at 85° C. for 15 hours then cooled to room temperature and filtered. The precipitate was washed with water and then dried to afford the title compound as an orange solid (159 g, 28%). 1H NMR (250 MHz, DMSO): δ 1.35 (t, 3H), 4.36 (q, 2H), 6.69 (s, 1H), 8.16 (s, 1H).

Aufarbeitung

  1. temperaturethen cooled to room temperature
  2. filtrationfiltered
  3. washThe precipitate was washed with water
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-e3eb65687a5b40aca63272abc8d1d7f7
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08846712B2

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