Ammonium Hydroxide → HCID 178461168, Verbindung
Reaktionsgleichung
S[C:2]1[N:3]=[C:4]([OH:12])[C:5]2[C@H:10]([CH3:11])[CH2:9][CH2:8][C:6]=2[N:7]=1.[NH4+].[OH-]>O.[Ni]>[CH3:11][C@H:10]1[C:5]2[C:4]([OH:12])=[N:3][CH:2]=[N:7][C:6]=2[CH2:8][CH2:9]1Komponenten
5
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
To a suspension of (R)-2-mercapto-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-ol (12 g, 65.8 mmol) in distilled water (100 mL) was added Raney Nickel (15 g) and NH4OH (20 mL). The mixture was refluxed for 3 hours then filtered, and the filtrate was concentrated to afford (R)-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-ol (9.89 g, 99%). MS (APCI+) [M+H]+151.
Aufarbeitung
- temperatureThe mixture was refluxed for 3 hours
- filtrationthen filtered
- concentrationthe filtrate was concentrated
Quellen und Nachweise
- ORD-Eintrag
- ord-9309701971a04d7a82d31fa78b347bd8
- Quelldatensatz
- uspto-grants-2014_09
- Patentnummer
- US08846681B2
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