Hydroxyamine hydrochloride → 17beta-Acetoxy-2,3-dihydroxyimino-5alpha-androstane

HRID 832

Reaktionsgleichung

Reaktionsgleichung von HRID 832
[OH:1][N:2]=[C:3]1[CH2:20][C@@:19]2([CH3:21])[C@@H:6]([CH2:7][CH2:8][C@@H:9]3[C@@H:18]2[CH2:17][CH2:16][C@@:14]2([CH3:15])[C@H:10]3[CH2:11][CH2:12][C@@H:13]2[OH:22])[CH2:5][C:4]1=O.[NH2:24][OH:25].Cl.[CH3:27][C:28]([O-:30])=O.[Na+].O>O>[C:28]([O:22][C@H:13]1[CH2:12][CH2:11][C@H:10]2[C@H:9]3[C@H:18]([CH2:17][CH2:16][C@:14]12[CH3:15])[C@:19]1([CH3:21])[C@H:6]([CH2:5][C:4](=[N:24][OH:25])[C:3](=[N:2][OH:1])[CH2:20]1)[CH2:7][CH2:8]3)(=[O:30])[CH3:27]

Komponenten

5

Edukt 3

HCID 443297Hydroxyamine hydrochlorideHCID 23681166Acetic acid, sodium salt, monohydrateHCID 867521632-Hydroxyimino-17beta-hydroxy-5alpha-androstan-3-one

Produkt 1

HCID 13639599017beta-Acetoxy-2,3-dihydroxyimino-5alpha-androstane

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A suspension of steroid 7, NH2OH.HCl and NaOAc/H2O was refluxed for 20 minutes. The reaction was cooled to room temperature and poured into H2O. The precipitate was collected by filtration. The resulting solid 8 was washed with H2O and air and dried; wt. 23.4 g.

Aufarbeitung

  1. temperaturewas refluxed for 20 minutes
  2. filtrationThe precipitate was collected by filtration
  3. washThe resulting solid 8 was washed with H2O and air
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-4fe7e7b0295444c08046dd75241f89c9
Quelldatensatz
uspto-grants-1998_03
Patentnummer
US05723455

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