Bromine → alpha-Bromo-2'-fluoro-4'-chloropropoxyacetophenone

HRID 8364

Reaktionsgleichung

Reaktionsgleichung von HRID 8364
[F:1][C:2]1[CH:7]=[C:6]([O:8][CH2:9][CH2:10][CH2:11][Cl:12])[CH:5]=[CH:4][C:3]=1[C:13](=[O:15])[CH3:14].[Br:16]Br.C(=O)(O)[O-].[Na+]>CCOCC>[Br:16][CH2:14][C:13]([C:3]1[CH:4]=[CH:5][C:6]([O:8][CH2:9][CH2:10][CH2:11][Cl:12])=[CH:7][C:2]=1[F:1])=[O:15]

Komponenten

5

Edukt 3

HCID 24408BromineHCID 516892Sodium BicarbonateHCID 69375838HCID 69375838, Verbindung

Produkt 1

HCID 22015593alpha-Bromo-2'-fluoro-4'-chloropropoxyacetophenone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

A solution of the product of Step A (2.3 g) in ether (10 mL) was treated with bromine (0.51 mL) and the mixture stirred for approximately 17 hours. The mixture was slowly poured into saturated sodium bicarbonate solution (40 mL) and then the organic layer was separated. The aqueous layer was washed with a fresh portion of ether (40 mL). The combined organic layers were washed with a fresh portion of water (50 mL), dried over magnesium sulfate, filtered and evaporated to give the title compound (3.1 g).

Aufarbeitung

  1. customthe organic layer was separated
  2. washThe aqueous layer was washed with a fresh portion of ether (40 mL)
  3. washThe combined organic layers were washed with a fresh portion of water (50 mL)
  4. dry with materialdried over magnesium sulfate
  5. filtrationfiltered
  6. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-15da65bf675c4180b4c07eda81b5323b
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07087757B2

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