1-Methyl-1,2,3,6-tetrahydropyridin-1-ium-5-carboxylic acid;chloride → 1-methylpiperidine-3-carboxylic Acid

HRID 840260Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 840260
[CH3:1][NH+:2]1[CH2:7][C:6]([C:8]([OH:10])=[O:9])=[CH:5][CH2:4][CH2:3]1.[Cl-]>O.[Pd]>[CH3:1][N:2]1[CH2:3][CH2:4][CH2:5][CH:6]([C:8]([OH:10])=[O:9])[CH2:7]1

Komponenten

4

Edukt 1

HCID 223681-Methyl-1,2,3,6-tetrahydropyridin-1-ium-5-carboxylic acid;chloride

Produkt 1

HCID 27369371-methylpiperidine-3-carboxylic AcidAusbeute 92 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 962WaterLösungsmittel

Versuchsvorschrift

Arecaidine hydrochloride (4 grams) (22.6 mmoles) was hydrogenated in water (100 ml) using 10% Pd—C at 40 psi at 25° C. for 24 hours. The catalyst was filtered off and washed with water. The aqueous solution was shaken with BioRad AG1X8 resin (OH− form) (23 ml bed) and after 5 minutes the resin was filtered off and washed with water. The aqueous solution was evaporated to give the title compound (Yield: 2.95 grams, 92%).

Aufarbeitung

  1. customat 25° C.
  2. customfor 24 hours
  3. filtrationThe catalyst was filtered off
  4. washwashed with water
  5. filtrationwas filtered off
  6. washwashed with water
  7. customThe aqueous solution was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-e32960a44d58439abe85c92dae1c6a57
Quelldatensatz
uspto-grants-2002_04
Patentnummer
US06365588B1

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