Diethyl (ethoxymethylene)malonate → HCID 178469604, Verbindung

HRID 842031Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 842031
[NH2:1][C:2]1[CH:3]=[N:4][C:5]([O:8][CH3:9])=[CH:6][CH:7]=1.CC[O:12][CH:13]=[C:14]([C:20](OCC)=O)[C:15]([O:17][CH2:18][CH3:19])=[O:16]>C1C=CC(C2C=CC=CC=2)=CC=1.C1C=CC(OC2C=CC=CC=2)=CC=1>[CH2:18]([O:17][C:15]([C:14]1[CH:20]=[N:1][C:2]2[C:3]([C:13]=1[OH:12])=[N:4][C:5]([O:8][CH3:9])=[CH:6][CH:7]=2)=[O:16])[CH3:19]

Komponenten

4

Edukt 2

HCID 6871Diethyl (ethoxymethylene)malonateHCID 811216-Methoxy-3-pyridinylamine

Produkt 1

HCID 178469604HCID 178469604, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 246701,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene)Lösungsmittel

Versuchsvorschrift

3-Amino-6-methoxypyridine (12.41 g) and diethyl ethoxymethylene malonate (20.2 ml) in Dowtherm A (400 ml) was heated at reflux, under argon for 1 h. The cooled reaction mixture was poured onto pentane (1 litre). The precipiated solid was collected by filration, washing with pentane. Drying afforded the title compound (24.78 g, crude).

Aufarbeitung

  1. temperatureat reflux, under argon for 1 h
  2. customThe cooled reaction mixture
  3. additionwas poured onto pentane (1 litre)
  4. customThe precipiated solid was collected by filration
  5. washwashing with pentane
  6. customDrying

Quellen und Nachweise

ORD-Eintrag
ord-27a56546be5447379649e7eaa7c418c0
Quelldatensatz
uspto-grants-2002_04
Patentnummer
US06372757B1

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