Pyruvic Acid → 2-(2,3,4-Trifluoroanilino)propionic acid

HRID 8438

Reaktionsgleichung

Reaktionsgleichung von HRID 8438
[F:1][C:2]1[C:7]([F:8])=[C:6]([F:9])[CH:5]=[CH:4][C:3]=1[N+:10]([O-])=O.[C:13]([OH:18])(=[O:17])[C:14]([CH3:16])=O.[H][H]>C(O)(C)C.[Pd]>[F:1][C:2]1[C:7]([F:8])=[C:6]([F:9])[CH:5]=[CH:4][C:3]=1[NH:10][CH:14]([CH3:16])[C:13]([OH:18])=[O:17]

Komponenten

6

Edukt 3

HCID 1060Pyruvic AcidHCID 698711,2,3-Trifluoro-4-nitrobenzeneHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 220158662-(2,3,4-Trifluoroanilino)propionic acidAusbeute 98,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 3776IsopropanolLösungsmittel

Versuchsvorschrift

2,3,4-Trifluoronitrobenzene (5.03 g) and pyruvic acid (2.75 g) were dissolved in isopropanol (IPA; 40 ml). After adding 10% Pd—C (0.21 g), the mixture was stirred at 40° C. under atmospheric pressure in a hydrogen atmosphere for 3 hours. After filtering off Pd—C, the obtained filtrate was concentrated under reduced pressure. Thus the title compound (6.11 g) was obtained as colorless crystals. Various spectral data of this product was identical with those of a specimen synthesized separately.

Aufarbeitung

  1. filtrationAfter filtering off Pd—C
  2. concentrationthe obtained filtrate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-d2ae1fef10194c6597c1745779551014
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07087778B2

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