Pyruvic Acid → 2-(2,3,4-Trifluoroanilino)propionic acid

HRID 8440

Reaktionsgleichung

Reaktionsgleichung von HRID 8440
[F:1][C:2]1[C:7]([F:8])=[C:6]([F:9])[CH:5]=[CH:4][C:3]=1[N+:10]([O-])=O.[C:13]([OH:18])(=[O:17])[C:14]([CH3:16])=O>CO.[Pd]>[F:1][C:2]1[C:7]([F:8])=[C:6]([F:9])[CH:5]=[CH:4][C:3]=1[NH:10][CH:14]([CH3:16])[C:13]([OH:18])=[O:17]

Komponenten

5

Edukt 2

HCID 1060Pyruvic AcidHCID 698711,2,3-Trifluoro-4-nitrobenzene

Produkt 1

HCID 220158662-(2,3,4-Trifluoroanilino)propionic acidAusbeute 96 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
40 °C

Versuchsvorschrift

2,3,4-Trifluoronitrobenzene (1.01 g) and pyruvic acid (0.75 g) were dissolved in methanol (8 ml). After adding 5% Pd—C (0.11 g), the mixture was stirred at 40° C. under a hydrogen gas pressure of 4.9 MPa (converted from 50 kgf/cm2) for 5 hours. After filtering off Pd—C, the obtained filtrate was concentrated under reduced pressure. Thus the title compound (1.20 g) was obtained as colorless crystals. Various spectral data of this product was identical with those of a specimen synthesized separately.

Aufarbeitung

  1. filtrationAfter filtering off Pd—C
  2. concentrationthe obtained filtrate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-4fb047e8329c4843bff603683d0831d1
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07087778B2

Verknüpfte Notizen

Wird geladen…