Pyruvic Acid → 2-(2,3,4-Trifluoroanilino)propionic acid

HRID 8441

Reaktionsgleichung

Reaktionsgleichung von HRID 8441
[F:1][C:2]1[C:8]([F:9])=[C:7]([F:10])[CH:6]=[CH:5][C:3]=1[NH2:4].[C:11]([OH:16])(=[O:15])[C:12]([CH3:14])=O.[H][H]>CC(O)C.[Pd]>[F:1][C:2]1[C:8]([F:9])=[C:7]([F:10])[CH:6]=[CH:5][C:3]=1[NH:4][CH:12]([CH3:14])[C:11]([OH:16])=[O:15]

Komponenten

6

Edukt 3

HCID 1060Pyruvic AcidHCID 774682,3,4-TrifluoroanilineHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 220158662-(2,3,4-Trifluoroanilino)propionic acidAusbeute 91,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 3776IsopropanolLösungsmittel

Versuchsvorschrift

2,3,4-Trifluoroaniline (4.18 g) and pyruvic acid (2.75 g) were dissolved in IPA (40 ml). After adding 10% Pd—C (0.21 g), the mixture was stirred at 40° C. under atmospheric pressure in a hydrogen atmosphere for 3 hours. After filtering off Pd—C, the obtained filtrate was concentrated under reduced pressure. Thus the title compound (5.69 g) was obtained as colorless crystals. Various spectral data of this product was identical with those of a specimen synthesized separately.

Aufarbeitung

  1. filtrationAfter filtering off Pd—C
  2. concentrationthe obtained filtrate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-fb9e8a6076c244cb9ed9b7dc84a1a78e
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07087778B2

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