Methane → Ethyl 2-(2-Amino-4-thiazolyl)-2-oxoacetate

HRID 845420

Reaktionsgleichung

Reaktionsgleichung von HRID 845420
Br[CH2:2][C:3]([C:5](=[O:11])[C:6]([O:8][CH2:9][CH3:10])=[O:7])=O.[NH2:12][C:13]([NH2:15])=[S:14].C>O.C(O)C>[NH2:15][C:13]1[S:14][CH:2]=[C:3]([C:5](=[O:11])[C:6]([O:8][CH2:9][CH3:10])=[O:7])[N:12]=1

Komponenten

6

Edukt 3

HCID 297MethaneHCID 2723790ThioureaHCID 13455954Ethyl bromoacetylglyoxylate

Produkt 1

HCID 4356513Ethyl 2-(2-Amino-4-thiazolyl)-2-oxoacetate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

195 g of ethyl bromoacetylglyoxylate are added dropwise to a solution of 66 g of thiourea in 450 ml of water and 450 ml of ethanol at 5° and after the addition has ended, the mixture is stirred at room temperature for 30 minutes and at 50° for 30 minutes and, after adding active charcoal, the resulting reaction mixture is then filtered. The filtrate is brought to pH 7 by adding sodium bicarbonate solution, whereupon ethyl 2-amino-thiazol-4-ylglyoxylate crystallizes out in crystals of melting point 147°.

Aufarbeitung

  1. additionafter the addition
  2. customthe resulting reaction mixture
  3. filtrationis then filtered
  4. additionby adding sodium bicarbonate solution
  5. customwhereupon ethyl 2-amino-thiazol-4-ylglyoxylate crystallizes out in crystals of melting point 147°

Quellen und Nachweise

ORD-Eintrag
ord-069cd5510cce44cdbc7e5074dd7aaca7
Quelldatensatz
uspto-grants-1988_07
Patentnummer
US04758556

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