Acetic Acid → 3-(3-Nitrophenyl)-3-(3-methoxyphenylthio)-1-phenyl-1-propanone

HRID 846217Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 846217
N1CCCCC1.[N+:7]([C:10]1[CH:11]=[C:12]([CH:23]=[CH:24][CH:25]=1)[CH:13]=[CH:14][C:15]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[O:16])([O-:9])=[O:8].[CH3:26][O:27][C:28]1[CH:29]=[C:30]([SH:34])[CH:31]=[CH:32][CH:33]=1.C(O)(=O)C>C1C=CC=CC=1.O>[N+:7]([C:10]1[CH:11]=[C:12]([CH:13]([S:34][C:30]2[CH:31]=[CH:32][CH:33]=[C:28]([O:27][CH3:26])[CH:29]=2)[CH2:14][C:15]([C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)=[O:16])[CH:23]=[CH:24][CH:25]=1)([O-:9])=[O:8]

Komponenten

7

Edukt 4

HCID 176Acetic AcidHCID 8082PiperidineHCID 849893-MethoxybenzenethiolHCID 948623-Nitrochalcone

Produkt 1

HCID 198847963-(3-Nitrophenyl)-3-(3-methoxyphenylthio)-1-phenyl-1-propanone

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 241BenzeneLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

Piperidine, 1.2 ml, was added to a boiling solution of 3-nitrobenzalacetophenone (10 g, 0.04 mole) and 3-methoxybenzenethiol (6.64 g, 0.048 mole) in 100 ml benzene . After standing for 30 minutes without further heating, acetic acid, 10 ml, was added. The solution then was poured into water (about 100 ml), extracted with methylene chloride (5×100 ml), washed with water, dried (Na2SO4) and evaporated to dryness to yield the title compound as a solid, mp 105°.

Aufarbeitung

  1. additionwas added
  2. extractionextracted with methylene chloride (5×100 ml)
  3. washwashed with water
  4. dry with materialdried (Na2SO4)
  5. customevaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-4deb0d0a7a0641ad98eff39a7c0d6dec
Quelldatensatz
uspto-grants-1992_08
Patentnummer
US05135940

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