6-Benzylpyridin-2-amine → 2-Imino-6-cyclohexylmethylpiperidine

HRID 849159

Reaktionsgleichung

Reaktionsgleichung von HRID 849159
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:3]=1>C(O)(=O)C.[Pt]=O>[NH:1]=[C:2]1[CH2:7][CH2:6][CH2:5][CH:4]([CH2:8][CH:9]2[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14]2)[NH:3]1

Komponenten

4

Edukt 1

HCID 939026-Benzylpyridin-2-amine

Produkt 1

HCID 1785075452-Imino-6-cyclohexylmethylpiperidine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 82844Platinum oxide (PtO)KatalysatorHCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

The 2-amino-6-benzylpyridine product of Example 298 A was reduced in acetic acid under hydrogen atmosphere utilizing platinum oxide catalyst to afford 2-imino-6-cyclohexylmethylpiperidine as an oil. The oil was dissolved in 1N HCl and lyophilized to give a white solid. The solid was recrystallized from EtOAc to give the title product as white crystals.

Quellen und Nachweise

ORD-Eintrag
ord-c54b6b59a77b4a6d895f822e4a0e7eee
Quelldatensatz
uspto-grants-2000_01
Patentnummer
US06011028

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