Diethyl Ether → 4-(2-Bromoacetyl)-4-phenylpiperidine hydrobromide

HRID 849328Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 849328
[Br:1]Br.[BrH:3].[C:4]([C:7]1([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1)(=[O:6])[CH3:5].CCOCC>C(Cl)Cl>[BrH:1].[Br:3][CH2:5][C:4]([C:7]1([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:8][CH2:9][NH:10][CH2:11][CH2:12]1)=[O:6]

Komponenten

5

Edukt 3

HCID 3283Diethyl EtherHCID 24408BromineHCID 212004624-Acetyl-4-phenylpiperidine hydrobromide

Produkt 1

HCID 227417564-(2-Bromoacetyl)-4-phenylpiperidine hydrobromideAusbeute 93,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

7.9 g of bromine are added rapidly at RT to a suspension of 14 g of 4-acetyl-4-phenylpiperidine hydrobromide in 200 ml of DCM and the reaction mixture is stirred overnight at RT. It is diluted by the addition of 200 ml of ether and the precipitate formed is wrung and washed with ether to give 16.7 g of the expected product after drying under vacuum.

Aufarbeitung

  1. customthe precipitate formed
  2. washwashed with ether

Quellen und Nachweise

ORD-Eintrag
ord-da05b1f1be2b4cde97eb3f95fed7f945
Quelldatensatz
uspto-grants-2000_01
Patentnummer
US06011154

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