Sodium Iodide → Benzene, 1-(4-iodo-1-butyn-1-yl)-4-(trifluoromethyl)-

HRID 852359Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 852359
[F:1][C:2]([F:19])([F:18])[C:3]1[CH:8]=[CH:7][C:6]([C:9]#[C:10][CH2:11][CH2:12]OS(C)(=O)=O)=[CH:5][CH:4]=1.[Na+].[I-:21]>CC(=O)CC>[I:21][CH2:12][CH2:11][C:10]#[C:9][C:6]1[CH:7]=[CH:8][C:3]([C:2]([F:19])([F:18])[F:1])=[CH:4][CH:5]=1

Komponenten

4

Edukt 2

HCID 5238Sodium IodideHCID 86602536Methanesulfonic acid 4-(4-trifluoromethyl-phenyl)-but-3-ynyl ester

Produkt 1

HCID 69458210Benzene, 1-(4-iodo-1-butyn-1-yl)-4-(trifluoromethyl)-Ausbeute 98,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6569Methyl Ethyl KetoneLösungsmittel

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

To a solution of 3.16 g (10.81 mmol) methanesulfonic acid 4-(4-trifluoromethyl-phenyl)-but-3-ynyl ester in 100 ml 2-butanone was added 3.24 g (21.62 mmol) NaI. The mixture was heated for 2 h at 90° C. The solvent was evaporated and the residue suspended in dichloromethane, ether was added and the suspension was filtrated. Evaporation of the organic phase gave 3.46 g of the title compound as an orange liquid.

Aufarbeitung

  1. customThe solvent was evaporated
  2. additionether was added
  3. filtrationthe suspension was filtrated
  4. customEvaporation of the organic phase

Quellen und Nachweise

ORD-Eintrag
ord-83e01209fab64aa5b919d9764167e053
Quelldatensatz
uspto-grants-2007_08
Patentnummer
US07253192B2

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