Acetic Acid → HCID 68008943, Verbindung

HRID 85328

Reaktionsgleichung

Reaktionsgleichung von HRID 85328
[C:1]([OH:4])(=[O:3])[CH3:2].[CH2:5]([O:12][C:13]1[CH:14]=[C:15]([CH2:19][CH2:20][CH2:21][CH2:22][NH:23][CH2:24][CH2:25][CH2:26][CH2:27]O)[CH:16]=[CH:17][CH:18]=1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>O>[C:1]([O:4][CH2:27][CH2:26][CH2:25][CH2:24][NH:23][CH2:22][CH2:21][CH2:20][CH2:19][C:15]1[CH:16]=[CH:17][CH:18]=[C:13]([O:12][CH2:5][C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:14]=1)(=[O:3])[CH3:2]

Komponenten

4

Edukt 2

HCID 176Acetic AcidHCID 680090004-[(3-Benzyloxyphenyl)butylamino]-1-butanol

Produkt 1

HCID 68008943HCID 68008943, VerbindungAusbeute 88 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

To 10 ml of anhydrous acetic acid was added 2.7 g (8.2 mmol) of 4-[(3-benzyloxyphenyl)butylamino]-1-butanol and the mixture was stirred with heating at 80° C. for 1 hour. The reaction mixture was poured into 150 ml of water and subjected to extraction with ethyl acetate. Washing was performed with a saturated sodium bicarbonate solution and then with a saturated saline solution. Drying over anhydrous sodium sulfate and concentration were performed. The residue was purified by silica gel column chromatography to give 2.68 g of a colorless oily matter (yield: 88.0%).

Aufarbeitung

  1. extractionsubjected to extraction with ethyl acetate
  2. washWashing
  3. dry with materialDrying over anhydrous sodium sulfate and concentration
  4. customThe residue was purified by silica gel column chromatography
  5. customto give 2.68 g of a colorless oily matter (yield: 88.0%)

Quellen und Nachweise

ORD-Eintrag
ord-c3dd087daabe4927b0368f1600ef1f5d
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08846955B2

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