Water → N-[(4-benzothiazol-2-yl)phenyl]-4-methylbenzenesulfonamide

HRID 857072

Reaktionsgleichung

Reaktionsgleichung von HRID 857072
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:9][C:10]3[CH:16]=[CH:15][CH:14]=[CH:13][C:11]=3[N:12]=2)=[CH:4][CH:3]=1.[C:17]1([CH3:27])[CH:22]=[CH:21][C:20]([S:23](Cl)(=[O:25])=[O:24])=[CH:19][CH:18]=1.O>N1C=CC=CC=1>[S:9]1[C:10]2[CH:16]=[CH:15][CH:14]=[CH:13][C:11]=2[N:12]=[C:8]1[C:5]1[CH:4]=[CH:3][C:2]([NH:1][S:23]([C:20]2[CH:21]=[CH:22][C:17]([CH3:27])=[CH:18][CH:19]=2)(=[O:25])=[O:24])=[CH:7][CH:6]=1

Komponenten

5

Edukt 3

HCID 962WaterHCID 73974-Toluenesulfonyl chlorideHCID 2344752-(4-Aminophenyl)benzothiazole

Produkt 1

HCID 4380499N-[(4-benzothiazol-2-yl)phenyl]-4-methylbenzenesulfonamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel2×

Versuchsvorschrift

To 2-(4-aminophenyl)-benzothiazole (0.5 g, 2.2 mmol) in pyridine (6 mL) was added para-toluenesulphonyl chloride (0.506 g, 2.7 mmol, 1.5 equiv.) in pyridine (4 mL). The reaction mixture was heated at reflux for 10 mins, then cooled and water (10 mL) added. The white precipitate formed was collected on a filter, washed with water and dried under vacuum to give N-[(4-benzothiazol-2-yl)phenyl]-4-methylbenzenesulfonamide as a white solid. The yield was 0.807 g (96%).

Aufarbeitung

  1. temperatureThe reaction mixture was heated
  2. temperatureat reflux for 10 mins
  3. temperaturecooled
  4. customThe white precipitate formed
  5. customwas collected on a filter
  6. washwashed with water
  7. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-72529ed308ac452380d4c4070f272ff0
Quelldatensatz
uspto-grants-2006_12
Patentnummer
US07144893B2

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