Hydrogen Bromide → 5-Bromo-2-(bromomethyl)-1,3-difluorobenzene
Reaktionsgleichung
[Br:1][C:2]1[CH:3]=[C:4]([F:11])[C:5]([CH2:9]O)=[C:6]([F:8])[CH:7]=1.[BrH:12].O>C(O)(=O)C>[Br:1][C:2]1[CH:3]=[C:4]([F:11])[C:5]([CH2:9][Br:12])=[C:6]([F:8])[CH:7]=1Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A solution of 5-Bromo-2-hydroxymethyl-1,3-difluoro-benzene (0.89 g, 4.0 mmol) and 30 wt % of hydrogen bromide in acetic acid was stirred at room temperature for 90 minutes before it was poured into 80 ml of water. The mixture was extracted with pentane (3×50 ml) and the combined organic layers were washed with water (3×20 ml), dried over MgSO4 and concentrated at low pressure to afford the desired product (10.0 g, 98% yield). 1H NMR (CDCl3) δ: 4.47 (s, 2H), 7.09–7.10 (m, 1H), 7.12–7.13 (m, 1H).
Aufarbeitung
- extractionThe mixture was extracted with pentane (3×50 ml)
- washthe combined organic layers were washed with water (3×20 ml)
- dry with materialdried over MgSO4
- concentrationconcentrated at low pressure
Quellen und Nachweise
- ORD-Eintrag
- ord-ba6e6e5c48cd4d03884cbd039f21ad81
- Quelldatensatz
- uspto-grants-2006_12
- Patentnummer
- US07148226B2
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